Targeting tumor antioxidant pathways with novel GSTP1/M2 inhibitors for cancer treatment
Greeshma P. Kumpati, Conor T. Ronayne, Joseph L. Johnson, Zachary S. Garder, Anuj Kumar Singh, Ananth Iyer, Venkatram R. Mereddy
This study designs and evaluates novel GSTP1/M2 inhibitors, finding that 5b effectively reduces tumor growth in vivo by overcoming gemcitabine resistance.
bioRxiv · Oct 20, 2025 · PreprintCancer Biology