Repurposing mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 for cancer therapy
Tanner J. Schumacher, Ananth V. Iyer, Jon N. Rumbley, Conor T. Ronayne, Venkatram R. Mereddy
This study combines mitochondrial-targeting anthelmintics with a GLUT1 inhibitor to target cancer metabolism, showing enhanced efficacy by disrupting both glycolysis and mitochondrial respiration in breast cancer cells.
BMC Cancer · Nov 16, 2024Peer-reviewedCancer Biology