Developmental BiologybioRxivPreprint
The metabolic kinase LKB1 shapes the enteric nervous system bymitigating the oxidative stress and p53 activity
Anthony Lucas, Florence Appaix, Jordan Allard…·Chantal Thibert
This paper shows that LKB1 is essential for ENS development by reducing oxidative stress and p53 activity, leading to hypoganglionosis and digestive issues when LKB1 is lost.
DOI 10.1101/2025.06.10.658770