The metabolic kinase LKB1 shapes the enteric nervous system bymitigating the oxidative stress and p53 activity
Anthony Lucas, Florence Appaix, Jordan Allard, Marie Mével‐Aliset, Anca G. Radu, Florence Fauvelle, Bertrand Favier, Alexeï Grichine, Jochen Maurer, Pierre L. Hainaut, Laura Donatella Attardi, Marc Billaud, Sakina Torch, Chantal Thibert
This paper shows that LKB1 is essential for ENS development by reducing oxidative stress and p53 activity, leading to hypoganglionosis and digestive issues when LKB1 is lost.
bioRxiv · Jun 10, 2025 · PreprintDevelopmental Biology