RSV Downregulates IL-21/IL-21R On TFH Cells Via PD-L1 Induction In APCs Impairing Protective Humoral Responses
Rodrigo Benedetti Gassen, Tiago Fazolo, Deise Nascimento de Freitas, Thiago Jesus Borges, Fabio Maito, Daniel A. G. Bueno Mendes, Andre Bafica, Luiz Carlos Rodrigues, Ana Paula Duarte de Souza, Cristina Bonorino
This study shows RSV impairs TFH cell function by inducing PD-L1 on APCs, reducing IL-21 and its receptor, which weakens humoral immunity, but IL-21 treatment can restore immune responses and protect against RSV infection.
bioRxiv · Nov 8, 2017 · PreprintImmunology