AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models
María Clara Sellés, Juliana T.S. Fortuna, Magalí Cecilia Cercato, Luís E. Santos, Luciana Domett, Andre L.B. Bitencourt, Mariane Favero Carraro, Amanda Santos de Souza, Helena Janíčková, Caroline Vieira Azevedo, Henrique Correia Campos, Jorge Marcondes de Souza, Soniza Vieira Alves‐Leon, Vânia F. Prado, Marco A. M. Prado, , Sergio Teixeira Ferreira
This study shows that AAV-delivered scFv antibodies targeting Aβ oligomers protect synapses and rescue memory in Alzheimer's disease models.
Molecular Therapy · Nov 11, 2022Peer-reviewedNeuroscience