Marco A. M. Prado

This study shows that pS129 accumulation in M83 mice leads to structural atrophy, reduced functional connectivity, and hypoactivation in somatosensory areas.

The paper investigates how different striatal dopaminergic pathways contribute to visuomotor conditional learning, finding that only nigrostriatal DA is necessary for learning.

This study shows that striatal acetylcholine supports reversal learning by promoting state construction in reinforcement learning.

This study tracks how striatal α-synuclein seeding affects brain networks and cognitive flexibility in marmosets, showing multi-scale reorganization and impaired cognitive flexibility.

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

This study identifies how STIP1/HOP interacts with a-Syn to promote toxic oligomer formation in synucleinopathies.

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

The paper investigates sex differences in aSyn pathology progression in M83 mice using MRI and behavioral analysis, finding female resilience to neurodegeneration despite earlier motor symptom onset in males.

This study examines gradients of basal forebrain connectivity in the human cortex using multimodal imaging and finds reduced tethering between structural and functional connectivity in specific brain regions.

This study shows that AAV-delivered scFv antibodies targeting Aβ oligomers protect synapses and rescue memory in Alzheimer's disease models.

This study identifies neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model, showing early cognitive deficits and brain atrophy linked to prion-like spread of misfolded alpha-synuclein.

The paper develops a transgenic mouse model with a fluorescent caspase activity reporter to quantify nonapoptotic caspase activity in rodent brains and demonstrates its use in studying neurophysiological and stress-related effects.

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

This study shows that chronic activation of hM3Dq in microglia reduces neuroinflammation and sickness behavior in mice by modulating cytokine responses.