Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
Lorenzo Mattioni, Giulia Poggi, Celine Gallagher, Katrin Becker, Linh Le, Maja Papic, Jasmin Engbers, Maija-Kreetta Koskinen, Ali Abdollahzadeh, David P. Herzog, Leonardo Nardi, Andrea Conrad, Sarah Winterberg, Christa Merte-Grebe, Liana Melo-Thomas, , Giulia Treccani
This study shows that deleting glucocorticoid receptors in postnatal oligodendrocyte precursor cells reduces oligodendrocyte density, alters hippocampal activity, and impairs memory in adult mice.
Proceedings of the National Academy of Sciences · Jul 20, 2026Peer-reviewedNeuroscience