Ari Waisman

This study shows OTUB1 stabilizes RelA by preventing its ubiquitination and degradation, which is crucial for controlling marginal zone B-cell development through CD40-dependent NF-κB signaling.

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

This study shows that deleting glucocorticoid receptors in postnatal oligodendrocyte precursor cells reduces oligodendrocyte density, alters hippocampal activity, and impairs memory in adult mice.

This study identifies XPC as essential for protecting Th17 cells from oxidative DNA damage, showing its role in DNA repair, differentiation, and function.

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

This study shows that gut microbiome changes in multiple sclerosis patients influence autoimmune neuroinflammation differently depending on disease stage.

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

This study shows that cerebral ischaemic stroke alters mucosal IgA responses and host-commensal microbiota interactions, leading to changes in intestinal microbiota composition.

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

This study establishes a novel mouse model of prenatal IL-17A imprinting, showing embryo-restricted responses lead to behavioral deficits in offspring.

This study identifies meningeal IL-17-producing T cells as a key driver of cognitive impairment in hypertension, showing their role in activating brain macrophages and suggesting therapeutic targets.

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.

The paper investigates how systemic inflammation affects synaptic plasticity using repetitive magnetic stimulation and shows that anti-inflammatory cytokines can restore plasticity in inflamed tissue cultures.

The paper uses single-cell transcriptomics and fate potential assays to map the erythroid differentiation trajectory from multipotent hematopoietic stem cells in mice, revealing novel regulators and transcriptional programs.