Structural Dynamics of the Dopamine D2 Receptor with a Non-Basic Ligand
Qinxin Sun, Guodong He, Damian Bartuzi, Andrea Garcia Silva, Ewa Kędzierska, Piotr Stępnicki, Anna Adamus, Katarzyna M. Targowska‐Duda, Tomasz M. Wróbel, Marian Castro, Jens Carlsson, Xiangyu Liu, Agnieszka Anna Kaczor
The paper presents a cryo-EM structure of the dopamine D2 receptor bound to a non-basic ligand, revealing structural dynamics and binding energy landscapes that explain subtype selectivity.
bioRxiv · Feb 11, 2026 · PreprintPharmacology & Toxicology