Author

Guodong He

Tsinghua UniversityORCID 0000-0002-3593-9574Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Guodong He1 paper

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Qinxin SuniD· 3 shared Xiangyu LiuiD· 3 shared Chuangye YaniD· 2 shared Fang KongiD· 2 shared Shuhao ZhangiD· 2 shared Xiaoou SuniD· 2 shared Xinyu XuiD· 2 shared Agnieszka Anna KaczoriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Qinxin SunORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structural Dynamics of the Dopamine D2 Receptor with a Non-Basic Ligand

Qinxin Sun, Guodong He, Damian Bartuzi, Andrea Garcia Silva, Ewa Kędzierska, Piotr Stępnicki, Anna Adamus, Katarzyna M. Targowska‐Duda, Tomasz M. Wróbel, Marian Castro, Jens Carlsson, Xiangyu Liu, Agnieszka Anna Kaczor

The paper presents a cryo-EM structure of the dopamine D2 receptor bound to a non-basic ligand, revealing structural dynamics and binding energy landscapes that explain subtype selectivity.

bioRxiv · Feb 11, 2026 · PreprintPharmacology & Toxicology

A pan-positive allosteric modulator that mediates sustainable GPCR activation

Qinxin Sun, Guodong He, Xinyu Xu, Fang Kong, Shuhao Zhang, Xiaoou Sun, Chuangye Yan, Xiangyu Liu

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

bioRxiv · Mar 24, 2025 · PreprintBiochemistry

A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator

Guodong He, Qinxin Sun, Xinyu Xu, Fang Kong, Shuhao Zhang, Kexin Ye, Xiaoou Sun, Xin Chen, Chuangye Yan, Xiangyu Liu

This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.

bioRxiv · Mar 24, 2025 · PreprintBiochemistry