Jens Carlsson

The paper presents cryo-EM structures of the delta opioid receptor with PAMs, identifies a novel allosteric site, and describes a mechanism for enhanced binding and activation.

The paper presents a cryo-EM structure of the dopamine D2 receptor bound to a non-basic ligand, revealing structural dynamics and binding energy landscapes that explain subtype selectivity.

The paper identifies a constitutively active mutant of the dopamine D2 receptor using computational methods and experimental validation.

This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.