Andrea Jaruffe Pinilla

In reanalyzed PXD016245 monocyte-differentiation proteomes, eight predefined protein-module scores retain a joint condition association (incremental R^2 0.313663, permutation p = 0.0002) beyond source block and day.

The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.