A Falsifiable Framework for Testing Neutralityin T-Cell Receptor Repertoire Databases
Roberto Navarro Quiroz, Andrea Jaruffe Pinilla, Katherine Escorcia, Jahaziel Perez Castillo, Lorenzo Salamanca Neita, Eloina Zarate Peñate, Lisandro Pacheco-Lugo, Leonardo C. Pacheco‐Londoño, Antonio J. Acosta-Hoyos, Diana Pava Garzon, Elkin Navarro Quiroz
The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.
bioRxiv · Dec 8, 2025 · PreprintBioinformatics