Roberto Navarro Quiroz

Longitudinal proteomic module profiles vary across human monocyte differentiation and polarization conditions

In reanalyzed PXD016245 monocyte-differentiation proteomes, eight predefined protein-module scores retain a joint condition association (incremental R^2 0.313663, permutation p = 0.0002) beyond source block and day.

Hierarchical bounds on RNA chromatin statistical dependence across cellular states in paired single-cell multiome data

The paper quantifies RNA-chromatin statistical dependence across cellular states using paired single-cell RNA-seq and ATAC-seq data, finding that most dependence is due to cell-type composition rather than regulatory coordination.

State-Dependent Regulatory Compression: Chromatin Geometry Gates Information Flow in Hematopoiesis

The paper identifies regulatory compression as an organizational principle in hematopoiesis, showing how chromatin geometry influences information flow through selective pathways in progenitor and differentiated cells.

State-dependent geometric constraints reveal a regulatory gate in hematopoietic progenitors

The paper analyzes geometric constraints in chromatin accessibility and gene expression in hematopoietic progenitors, finding that forbidden zones indicate a regulatory gate rather than informational independence.

Immune gene co-expression networks are constrained by a non-linear topology spectral relationship

The paper analyzes immune gene co-expression networks across two cohorts and finds that neither modularity nor spectral dominance alone distinguishes healthy from disease states, but their joint distribution reveals a geometric constraint.

A Falsifiable Framework for Testing Neutralityin T-Cell Receptor Repertoire Databases

The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.

Differential gene expression in the interactome of the Human Dopamine transporter in the context of Parkinson's disease

The paper identifies differential gene expression in the hDAT interactome in Parkinson's disease, finding 31 downregulated genes and 90 miRNAs regulating 27 interactome components.