Lisandro Pacheco-Lugo

Longitudinal proteomic module profiles vary across human monocyte differentiation and polarization conditions

In reanalyzed PXD016245 monocyte-differentiation proteomes, eight predefined protein-module scores retain a joint condition association (incremental R^2 0.313663, permutation p = 0.0002) beyond source block and day.

Immune gene co-expression networks are constrained by a non-linear topology spectral relationship

The paper analyzes immune gene co-expression networks across two cohorts and finds that neither modularity nor spectral dominance alone distinguishes healthy from disease states, but their joint distribution reveals a geometric constraint.

A Falsifiable Framework for Testing Neutralityin T-Cell Receptor Repertoire Databases

The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.