Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypes
Krissy A. Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez, Nicola J. Allen
This study identifies SEMA3C as an astrocyte-secreted protein contributing to Rett Syndrome pathology and shows its normalization rescues dendritic and behavioral deficits.
bioRxiv · Oct 10, 2025 · PreprintNeuroscience