Adrien Paumier

This study shows suppressing BMP signaling in astrocytes reduces molecular and functional deficits in fragile X syndrome.

This study identifies SEMA3C as an astrocyte-secreted protein contributing to Rett Syndrome pathology and shows its normalization rescues dendritic and behavioral deficits.

This study identifies pleiotrophin dysregulation in astrocytes as a contributor to neuronal structural and functional deficits in Down Syndrome, showing potential for therapeutic intervention.

This study shows astrocyte glypican 5 is necessary for synapse maturation and stabilization in the developing mouse cortex, with implications for neurological disorders.

The paper identifies glypican 5 downregulation in astrocytes as a contributor to synaptic dysfunction in Alzheimer's disease models and shows its reversal can improve cognitive function.

This study shows that TRPA1 channel blockade prevents Alzheimer's disease progression by normalizing astrocyte and neuronal activity in a mouse model.