Charting functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Alexander Hanzl, Ryan Casement, Hana Imrichová, Scott J. Hughes, Eleonora Barone, Andrea Testa, Sophie Bauer, Jane E. Wright, Matthias Brand, Alessio Ciulli, Georg E. Winter
The paper identifies functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders using haploid genetics and deep mutational scanning.
Nature Chemical Biology · Nov 3, 2022Peer-reviewedMolecular Biology