Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
Scott J. Hughes, Wojciech J. Stec, Colin T. R. Davies, David McGarry, Alicia Williams, Marta Carrara, Iván del Barco Barrantes, Rebecca Harris, Anna Tasegian, Dominic D. G. Owens, Alexander Fawcett, John Hellicar, Aleksandra Azevedo, Gregor P. Meier, Andrew C. Runcie, , Andrea Testa
The paper identifies a potent BRD9 degrader, AMPTX-1, which selectively recruits BRD9 to DCAF16, leading to its degradation in vivo.
Nature Communications · Oct 27, 2025Peer-reviewedBiochemistry