Author

Eleonora Barone

Austrian Academy of SciencesORCID 0000-0002-4788-7070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Georg E. WinteriD· 3 shared Alexander HanzliD· 2 shared Anna KoreniD· 2 shared Hana ImrichováiD· 2 shared Sophie BaueriD· 2 shared Stefan KubicekiD· 2 shared Alessio CiulliiD· 1 shared Andrea RukavinaiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Georg E. WinterORCID

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3 papers

Recent·Most cited

Molecular BiologyNaturePeer-reviewedNov 26, 2025

Inhibitor-induced supercharging of kinase turnover via endogenous proteolytic circuits

Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus…·Georg E. Winter

The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.

34 citationstop 1%

humanproteomics

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Molecular BiologyJournal of the American Chemical SocietyPeer-reviewedJan 5, 2023

E3-specific degrader discovery by dynamic tracing of substrate receptor abundance

Alexander Hanzl, Eleonora Barone, Sophie Bauer…·Georg E. Winter

This paper develops a scalable method to identify E3-specific degraders by tracing substrate receptor abundance changes induced by pharmacological auto-degradation.

41 citations

humanproteomics

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Molecular BiologyNature Chemical BiologyPeer-reviewedNov 3, 2022

Charting functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Alexander Hanzl, Ryan Casement, Hana Imrichová…·Georg E. Winter

The paper identifies functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders using haploid genetics and deep mutational scanning.

132 citationstop 1%

experimental assaydrug response / drug discovery

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