Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley
Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud, Jürgen Hench, Tim E. Moors, Paula P. Navarro, Daniel Castaño‐Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N. Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela M. T. Ingrassia, Yvonne de Gier, Annemieke J.M. Rozemüller, , Matthias E. Lauer
The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.
Nature Neuroscience · Jun 24, 2019Peer-reviewedNeuroscience