Sarah H. Shahmoradian

Large-Scale Mutagenesis Identifies Sequence Changes That Bias Tau Toward CTE-like Aggregation

The paper identifies sequence changes that bias tau aggregation toward CTE-like structures using mutagenesis and structural analysis.

TIR-like NADases act in bacterial immunity and the RNA vault

This study identifies DUF4062 as TIR-like NADases involved in bacterial antiphage defense and eukaryotic RNA vault function through structural and biochemical analyses.

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells

This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

Correlative light and electron microscopy for human brain and other biological models

This paper provides a protocol for correlative light and electron microscopy (CLEM) optimized for analyzing human brain tissue, enabling detailed ultrastructural analysis and characterization of subcellular features.

Functional classification of tauopathy strains reveals the role of protofilament core residues.

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.

Cryo-EM structure of Alzheimer disease tau filaments with PET ligand MK-6240

The paper determines the cryo-EM structure of Alzheimer's disease tau filaments bound by the PET ligand MK-6240, revealing key binding interactions that inform ligand design.

Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography

This study uses cryo-electron tomography to analyze the structure of mutant huntingtin exon 1 and polyQ aggregates, revealing structural heterogeneity and a 'polyQ core' model.

Micrometer-resolution reconstruction and analysis of whole mouse brain vasculature by synchrotron-based phase-contrast tomographic microscopy

The paper presents a method for high-resolution reconstruction of whole mouse brain vasculature using synchrotron-based tomography and analyzes its structural properties.

Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley

The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.