Antigen affinity and site of immunization dictate B cell recall responses
Manon Termote, Rafael C. Marques, Erik Hyllner, Mariia V. Guryleva, Mirthe Henskens, Andreas Brutscher, Isabel J.L. Baken, Xaquin Castro Dopico, Adria Dalmau Gasull, Ben Murrell, Leonidas Stamatatos, Lisa S. Westerberg, Pia Dosenovic
This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.
bioRxiv · Apr 19, 2024Immunology