Mariia V. Guryleva

This paper introduces PhyloTrajectory, a method that uses TCR clonotype frequencies and scRNA-seq to infer T cell differentiation trajectories.

The paper uses spatial and single-cell techniques to show T and B cell clonal expansion in CXCL9-rich niches of sinonasal cancer, linking immune hubs to tumor regions.

This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.