Leonidas Stamatatos

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

Fc receptor dependent and independent mechanisms of antibody-mediatedenhancement of immune responses

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodies

This study shows that higher valency immunogens promote the maturation of VRC01-class antibodies with broader neutralizing activity in animals.

Antigen affinity and site of immunization dictate B cell recall responses

This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (2020/01 - 2021/03) Using a Statistical Learning Strategy

The paper uses a statistical learning strategy to track SARS-CoV-2 Spike protein mutations in the US, identifying new variants and their spatiotemporal patterns.