Mouse precision-cut liver and kidney slices: an optimized ex vivo model for acute toxicity testing
Christiane Spruck, Ghizlan Bousejra, Ahmed Erbay, Sonja Herbrich, Andreas Dimitriadis, Zoe Röntgen, Frauke Roolfs, Isaac Musong Mboni-Johnston, Gerhard Fritz, Seddik Hammad, Nicole Schupp
This paper develops an optimized ex vivo model using mouse precision-cut liver and kidney slices for acute toxicity testing, showing comparable sensitivity and reproducibility to in vivo models.
bioRxiv · Jul 21, 2025 · PreprintPharmacology & Toxicology