Seddik Hammad

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

Endogenous immunoglobulin G (IgG) immunostaining quantitatively labels apoptotic and necrotic hepatocytes across acute and chronic murine liver injury models, outperforming serum transaminases and histopathological Ishak scoring.

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

This paper develops a digital twin model to simulate liver fibrosis patterns, showing that ECM distribution results from cell death zones and biomechanical compression.

This paper develops an optimized ex vivo model using mouse precision-cut liver and kidney slices for acute toxicity testing, showing comparable sensitivity and reproducibility to in vivo models.

This paper introduces a semi-automated protocol for isolating multiple liver cell types from mouse and human livers with high yield, purity, and viability.

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

This study shows that targeting scavenger receptors Stabilin-1 and Stabilin-2 reduces atherosclerosis by altering the plasma proteome, which suppresses monocyte/macrophage activity.

This study identifies microsteatosis and mild inflammation as key features of liver tolerance to repeated toxic injuries, using a mouse model and multi-omics analysis.