Gerhard Fritz

This study examines prolonged stress responses of breast carcinoma cells after hypofractionated irradiation in vitro and in vivo, identifying adaptive changes in DNA repair, apoptosis, and immune infiltration.

This paper develops an optimized ex vivo model using mouse precision-cut liver and kidney slices for acute toxicity testing, showing comparable sensitivity and reproducibility to in vivo models.

This study shows that Rac1 deletion reduces anthracycline-induced organ damage in mice, with effects varying by organ and drug type.

This study shows SIRT1 limits neuronal fate after DNA damage by promoting repair and preventing damaged DNA from propagating to neurons.

This study compares the response of murine embryonic stem cells and their endothelial progeny to doxorubicin and DNA repair inhibitors, finding differential susceptibility and functional impairments in differentiated cells.

This study identifies verapamil as a synergistic agent to overcome doxorubicin resistance in ovarian cancer cells by enhancing DNA damage and apoptosis.

This study shows that low-dose doxorubicin treatment of human iPSCs causes mitochondrial dysfunction and transcriptional changes that impair cardiac regeneration in derived cardiomyocytes.