Nuclear rerouting of paracrine Fgf3 in source cells represses target genes to pattern morphogen responses
Sevi Durdu, Murat Iskar, Alicia Roig‐Merino, Elisa Gallo, Ezgi Karaca, Andreas Kunze, Erika Doná, Peer Bork B, Dirk Schübeler, Darren T. Gilmour
The paper shows that Fgf3 in zebrafish lateral line organogenesis represses target genes through nuclear accumulation, distinct from its extracellular signaling role.
bioRxiv · Jul 24, 2025 · PreprintDevelopmental Biology