Sevi Durdu

The paper shows chromatin-opening transcription factors determine transcription start sites by binding near the initiation site, with loss of these factors redirecting initiation to secondary sites.

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

The paper identifies chromatin-dependent motif syntax that distinguishes binding patterns of NGN2 and MyoD1 during differentiation, revealing how context-specific chromatin states influence transcription factor specificity.

The paper shows that Fgf3 in zebrafish lateral line organogenesis represses target genes through nuclear accumulation, distinct from its extracellular signaling role.

This study shows that Trim24 restricts p53's ability to open chromatin by binding to closed chromatin regions and interacting with unmethylated histone H3 lysine 4.