Murat Iskar

The paper shows chromatin-opening transcription factors determine transcription start sites by binding near the initiation site, with loss of these factors redirecting initiation to secondary sites.

The paper benchmarks DNA methylation sequencing workflows against an experimental gold-standard, identifying superior workflows and developing a sustainable benchmarking platform.

The paper identifies chromatin-dependent motif syntax that distinguishes binding patterns of NGN2 and MyoD1 during differentiation, revealing how context-specific chromatin states influence transcription factor specificity.

The paper shows that Fgf3 in zebrafish lateral line organogenesis represses target genes through nuclear accumulation, distinct from its extracellular signaling role.

The paper shows that NURF subunit BPTF is critical for chromatin accessibility and CTCF function, affecting cohesin positioning and insulation.

This study shows that Trim24 restricts p53's ability to open chromatin by binding to closed chromatin regions and interacting with unmethylated histone H3 lysine 4.

This study rapidly generates proteomic data for NCI-60 cancer cell lines and identifies drug response determinants by integrating proteomic, genetic, and transcriptomic data.