The importance of charge in perturbing the aromatic glue stabilizing the protein-protein interface of homodimeric tRNA-guanine transglycosylase
Andreas Nguyen, Dzung Nguyen, Tran Xuan Phong Nguyen, Maurice Sebastiani, Stefanie Dörr, Oscar Hernandez‐Alba, François Debaene, Sarah Cianférani, A. Heine, Gerhard Klebe, Klaus Reuter
The paper investigates how charge affects the stability of the homodimeric tRNA-guanine transglycosylase (Tgt) interface, showing that protonation of a histidine destabilizes the dimer at acidic pH.
ACS Chemical Biology · Nov 9, 2020Peer-reviewedMolecular Biology