Sarah Cianférani

The paper introduces FAIMS-GPF XL-MS, a method for detecting protein-protein interactions using gas-phase fractionation, achieving high sensitivity and coverage without in-solution fractionation.

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

This paper develops a hydrogel that enables subcutaneous delivery of vesicant antibody-drug conjugates by confining them in a depot, reducing tissue damage while maintaining antitumor efficacy.

This study compares the effects of polystyrene and polylactide nanoparticles on macrophages under repeated exposure, showing adaptation and harmful effects.

This paper presents a methyl group assignment for the Fc fragment of an IgG1 antibody using NMR, enabling structural analysis of glycosylated Fc without isotopic labelling.

This study compares the effects of polyethylene terephthalate and polycaprolactone nanoparticles on macrophages under repeated exposure, showing differential responses in oxidative stress and function.

This study uses cryo-EM and HDX-MS to analyze GPBAR1-G protein interactions, revealing conformational dynamics and structural details of the complex.

This paper introduces a new synthetic strategy for phosphatidic acid analogues that preserves acyl chain structure and enables flexible molecular grafting for biological studies.

This study identifies 57 uranyl-binding proteins in Arabidopsis thaliana cells, with GRP7 showing specific U(VI) binding and interference with RNA binding, suggesting a role in uranium toxicity.

This study investigates the 3D structure and function of the human R2SP complex using biochemical and structural methods, revealing similarities to the canonical R2TP complex and differences in ATPase activity and adaptor binding.

This study examines the effects of polylactic acid nanoparticles on macrophages using proteomics and validation experiments, revealing adaptive changes and altered immune functions.

The paper investigates how charge affects the stability of the homodimeric tRNA-guanine transglycosylase (Tgt) interface, showing that protonation of a histidine destabilizes the dimer at acidic pH.

This study identifies structural and biophysical details of the MED1-VDR-RXR interaction, revealing new insights into coactivator recognition by nuclear receptor complexes.