A protein language model links the E. coli pangenome functional landscape geometry to host proteostasis
Daniel Martínez‐Martínez, Cassandra Backes, Aleksandra Zečić, Andreea Aprodu, Hannah M. Doherty, Jonas Widder, Ivan Andrew, Laurence Game, Iliyana Kaneva, Georgia Roumelioti, Alex Montoya, Holger Kramer, Filipe Cabreiro
The paper develops a pangenome framework using a protein language model to link E. coli genetic diversity to host proteostasis by analyzing functional guilds and metabolic interactions.
bioRxiv · Sep 30, 2026 · PreprintSystems Biology