Ivan Andrew

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

The paper develops a pangenome framework using a protein language model to link E. coli genetic diversity to host proteostasis by analyzing functional guilds and metabolic interactions.

This paper identifies and functionally assesses GPCRs during human adipogenesis, revealing novel expression patterns and therapeutic targets.

The paper identifies temporally distinct CDX-driven regionalisation events that preconfigure vagal and trunk neural crest identities in mouse embryos.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

X-CODE enables multi-platform clonal tracking and spatial phenotyping by combining RNA barcoding with sequencing and imaging technologies.

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

This study identifies systemic extracellular acidification as a conserved aging hallmark in flies and mice, linking it to mortality and acidosis susceptibility.

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

This study shows that IL11 expression in cardiomyocytes causes cardiac fibrosis, inflammation, and dysfunction, contradicting previous reports of its anti-fibrotic effects.