Laurence Gamé

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

The paper develops a pangenome framework using a protein language model to link E. coli genetic diversity to host proteostasis by analyzing functional guilds and metabolic interactions.

This paper identifies and functionally assesses GPCRs during human adipogenesis, revealing novel expression patterns and therapeutic targets.

The paper identifies temporally distinct CDX-driven regionalisation events that preconfigure vagal and trunk neural crest identities in mouse embryos.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

X-CODE enables multi-platform clonal tracking and spatial phenotyping by combining RNA barcoding with sequencing and imaging technologies.

This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.

The paper uses scRNA-seq and imaging to study gene expression heterogeneity in fission yeast under different environmental conditions, revealing how gene expression varies during growth and stress responses.