Holger Kramer

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

The paper develops a pangenome framework using a protein language model to link E. coli genetic diversity to host proteostasis by analyzing functional guilds and metabolic interactions.

This study identifies how Orientia tsutsugamushi uses ScaC to recruit BICD2 for dynein-based motility, revealing a mechanism for bacterial transport within host cells.

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.

This study identifies conserved helical motifs in Ikaros that mediate NuRD interaction and transcriptional repression in pre-B cells and B-ALL.

The paper shows that loss of H3K9 tri-methylation leads to smaller, more compact mitotic chromosomes and altered transcription factor retention.

This study investigates how growth rate and nutrient-specific factors influence gene expression in fission yeast, revealing coordinated and condition-specific regulation of metabolic enzymes.

The paper presents a modified density gradient method for isolating endo-lysosomal proteins from cardiac tissue and reports proteomic analysis of these fractions in guinea pigs.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

This study identifies an FGF2-mediated incoherent feedforward loop that inhibits Erk and promotes naive pluripotency in ES cells and embryos.

This study shows the human SKI complex prevents telomere instability by resolving DNA-RNA hybrids at telomeres during G2 phase.

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

This study shows that PP4 phosphatase dephosphorylates Rad53, enhancing DNA end resection and recombinational repair by counteracting Rad9's inhibitory effect on Sgs1/Dna2.