Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiation
Daria Bunina, Pierre‐Luc Germain, Alejandro Tobon, Nadine Fernandez-Novel Marx, Christian Arnold, Andrew Ahern, Annique Claringbould, Mang Ching Lai, Sampathkumar Rangasamy, Vinodh Narayanan, Peter Lorentzen, Karen M. Park, Antonio Adamo, Giuseppe Testa, Judith B. Zaugg, Kyung‐Min Noh
The paper identifies gene regulatory network disruptions caused by LSD1 mutations in early differentiation, showing impaired transcription factor activity and potential therapeutic targets through HDAC inhibition.
bioRxiv · Aug 11, 2021 · PreprintGenomics