Author

Mang Ching Lai

European Molecular Biology LaboratoryORCID 0000-0002-8183-6103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Annique ClaringbouldiD· 2 shared Christian ArnoldiD· 2 shared Daria BuninaiD· 2 shared Judith B. ZauggiD· 2 shared Alejandro ToboniD· 1 shared Andrew Ahern· 1 shared Anna MathioudakiiD· 1 shared Anne‐Claude GaviniD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersSystems Biology

Annique ClaringbouldORCID

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2 papers

Recent·Most cited

Enhancer-priming in ageing human bone marrow mesenchymal stromal cells contributes to immune traits

Mang Ching Lai, Mariana Ruiz-Velasco, Christian Arnold, Olga M. Sigalova, Daria Bunina, Ivan Berest, Ximing Ding, Marco L. Hennrich, Laura Poisa-Beiro, Annique Claringbould, Anna Mathioudaki, Caroline Pabst, Anthony Dick Ho, Anne‐Claude Gavin, Judith B. Zaugg

This study uses multiomics analysis of BMSCs to show age-related changes in enhancer activity and gene regulation contribute to immune traits and tissue-specific disorders.

bioRxiv · Sep 3, 2021 · PreprintSystems Biology

Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiation

Daria Bunina, Pierre‐Luc Germain, Alejandro Tobon, Nadine Fernandez-Novel Marx, Christian Arnold, Andrew Ahern, Annique Claringbould, Mang Ching Lai, Sampathkumar Rangasamy, Vinodh Narayanan, Peter Lorentzen, Karen M. Park, Antonio Adamo, Giuseppe Testa, Judith B. Zaugg, Kyung‐Min Noh

The paper identifies gene regulatory network disruptions caused by LSD1 mutations in early differentiation, showing impaired transcription factor activity and potential therapeutic targets through HDAC inhibition.

bioRxiv · Aug 11, 2021 · PreprintGenomics