Alejandro Tobon

The paper develops and validates multiplexing strategies for brain organoids combined with single cell RNA-seq to study neurodevelopmental trajectories across multiple genetic lines.

This study shows that GTF2I dosage affects neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders using patient-derived organoids and mouse models.

This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.

This study benchmarks brain organoid gene co-expression patterns against fetal corticogenesis to assess their alignment with in vivo development.

The paper identifies gene regulatory network disruptions caused by LSD1 mutations in early differentiation, showing impaired transcription factor activity and potential therapeutic targets through HDAC inhibition.

This study shows that a high ω-6 PUFA diet causes reversible peripheral nerve dysfunction and worsens pain in mice, with potential therapeutic implications.

This study shows that CHD8 haploinsufficiency disrupts human cortical development by altering neuron generation timing, leading to macrocephaly-like organoid enlargement and cell-type specific molecular defects.

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.