The nuclear import receptor Kapβ2 protein modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
M.E. Cicardi, V. Kankate, Sindhu Sriramoji, K. Krishnamurthy, Shashirekha S. Markandaiah, Brandie Morris Verdone, Amandeep Girdhar, Andrew T. Nelson, Linda Blake Rivas, Andrew Boehringer, Aaron R. Haeusler, Piera Pasinelli, Lin E. Guo, Davide Trotti
This study shows that Kapβ2 protein interacts with poly(GR) and reduces its neurotoxicity in C9orf72-linked ALS/FTD by improving neuron survival.
Communications Biology · Mar 28, 2024Peer-reviewedNeuroscience