Author
Thomas Jefferson UniversityORCID 0000-0003-2552-8912Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
M.E. Cicardi, Daniela Tejada-Martínez, Shashirekha S. Markandaiah…·Davide Trotti
CAR-T cells targeting uPAR selectively ablate pathogenic microglia while sparing neurons, enabling precision immunotherapy for ALS.
Dong-Woo Hwang, Karthik Krishnamurthy, Arya Nagare…·Sulagna Das
The paper uses single-molecule imaging to show activity-dependent localization and translation of Camk2a mRNA at dendritic spines, revealing a mechanism for maintaining CaMKII levels during synaptic plasticity.
Eva Martin‐Solana, Stephen D. Carter, Karthik Krishnamurthy…·Zachary Freyberg
The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.
M.E. Cicardi, V. Kankate, Sindhu Sriramoji…·Davide Trotti
This study shows that Kapβ2 protein interacts with poly(GR) and reduces its neurotoxicity in C9orf72-linked ALS/FTD by improving neuron survival.
M.E. Cicardi, Justin Hallgren, Darilang Mawrie…·Davide Trotti
This study shows that C9orf72 poly(PR) causes nucleolar stress and neurotoxicity, which can be mitigated by reducing p53 levels in fly and rat models.