Author
Thomas Jefferson UniversityPrimary ORCID profile (0000-0002-2591-0428 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Andrew T. Nelson, M.E. Cicardi, Shashirekha S. Markandaiah, John Ys Han, Nancy J. Philp, Emily M. Welebob, Aaron R. Haeusler, Piera Pasinelli, Giovanni Manfredi, Hibiki Kawamata, Davide Trotti
This study shows glucose hypometabolism in C9orf72-related ALS/FTD leads to DPR production, neuronal death, and motor dysfunction through GCN2 activation.
EMBO Reports · Apr 29, 2024Peer-reviewedNeuroscience
M.E. Cicardi, V. Kankate, Sindhu Sriramoji, K. Krishnamurthy, Shashirekha S. Markandaiah, Brandie Morris Verdone, Amandeep Girdhar, Andrew T. Nelson, Linda Blake Rivas, Andrew Boehringer, Aaron R. Haeusler, Piera Pasinelli, Lin E. Guo, Davide Trotti
This study shows that Kapβ2 protein interacts with poly(GR) and reduces its neurotoxicity in C9orf72-linked ALS/FTD by improving neuron survival.
Communications Biology · Mar 28, 2024Peer-reviewedNeuroscience
M.E. Cicardi, Justin Hallgren, Darilang Mawrie, K. Krishnamurthy, Shashirekha S. Markandaiah, Andrew T. Nelson, V. Kankate, Eric Nathaniel Anderson, Piera Pasinelli, Udai Bhan Pandey, Christine M. Eischen, Davide Trotti
This study shows that C9orf72 poly(PR) causes nucleolar stress and neurotoxicity, which can be mitigated by reducing p53 levels in fly and rat models.
iScience · Jul 28, 2023Peer-reviewedNeuroscience
Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky, Andrew T. Nelson, Luke W. Koblan, Aditya Raguram, Jonathan Ma Levy, Jaron A. M. Mercer, David R. Liu
This paper introduces twin prime editing (twinPE) and its combination with site-specific recombinases to enable precise DNA deletion, replacement, integration, and inversion in human cells without double-strand breaks.
bioRxiv · Nov 1, 2021 · PreprintGenomics
Eric J. Aird, Alina C. Zdechlik, Brian L. Ruis, Colette B. Rogers, Andrew C.D. Lemmex, Andrew T. Nelson, Eric A. Hendrickson, Daniel Schmidt, Wendy Ryan Gordon
This paper describes a split Staphylococcus aureus prime editor delivered by dual AAVs, demonstrating in vitro editing capacity despite lower-than-ideal efficiency.
bioRxiv · Jan 11, 2021 · PreprintMolecular Biology