Pooled genetic screens identify breast cancer risk genes involved in evasion from T cell-mediated killing
Wei Shi, Yi Luo, Jacqueline M. Burrows, Debra M. Black, Andrew Civitarese, Laura Perlaza-Jiménez, Ping Zhang, Murray Manning, Natasha Tuano, Miguel E. Rentería, Christos Xiao, Siok‐Keen Tey, Joseph Rosenbluh, Corey Smith, Georgia Chenevix‐Trench, Jonathan Beesley
The paper uses pooled CRISPR screens to identify breast cancer risk genes affecting T cell-mediated killing, finding 33 candidates and showing their impact on immune response and patient outcomes.
bioRxiv · May 10, 2024 · PreprintGenetics