Natasha Tuano

This study uses iPSC-derived muscle models to show that DUX4 base editing improves muscle function in childhood-onset FSHD.

This paper benchmarks spatial transcriptomics in stem cell-derived organoids using Stereo-seq, optimizing RNA capture and introducing regional analysis methods.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

The paper identifies SRP19 as a vulnerability in cancers with APC loss, showing that reducing SRP19 inhibits proliferation through ER stress.

The paper uses pooled CRISPR screens to identify breast cancer risk genes affecting T cell-mediated killing, finding 33 candidates and showing their impact on immune response and patient outcomes.

The paper maps chromatin interactions at 139 breast cancer risk signals using Capture Hi-C and identifies candidate target genes and functional mechanisms.