Laura Perlaza-Jiménez

This study integrates surveillance methods to profile AMR genotypes and phenotypes across diverse environmental and clinical samples, revealing high diversity and mismatches between genotype and phenotype.

This study investigates how horizontal gene transfer and selection drive microbial adaptation in Antarctic soils, finding widespread HGT of aerotrophy-related genes and strong purifying selection.

This study shows that dorso-ventral patterning genes in paired fins are conserved in median fins, supporting an ancient origin of the DV regulatory module that was redeployed during paired fin evolution.

This study uses Perturb-seq to analyze pharmacogenomic interactions in gastric cancer, revealing gene-drug relationships and resistance mechanisms.

The paper introduces SAM-DNMT3A, a CRISPR-based method to induce global DNA methylation, and shows it exploits a vulnerability in ER-positive breast cancers.

The paper identifies pathway-specific functional circular RNAs through loss-of-function screens in cancer cell lines, revealing roles in ferroptosis, WNT, and MAPK signaling.

The paper uses pooled CRISPR screens to identify breast cancer risk genes affecting T cell-mediated killing, finding 33 candidates and showing their impact on immune response and patient outcomes.

This study uses human kidney organoids to model hypoxic injury and maladaptive repair, identifying molecular and metabolic changes associated with AKI and CKD progression.

This study uses correlated mutations to detect macromolecular and chromatin interactions in Arabidopsis thaliana using genome-wide sequence data.