BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD
Uyen Tran, Andrew J. Streets, Devon Smith, Decker Eva, Annemarie Kirschfink, Lahoucine Izem, Jessie M Hassey, Briana Rutland, Manoj Kumar Valluru, Jan Hinrich Bräsen, Elisabeth B. Ott, Daniel Epting, Tobias Eisenberger, Albert C.M. Ong, Carsten Bergmann, Oliver Wessely
This study shows BICC1 interacts with PKD1 and PKD2, exacerbating ADPKD severity through RNA metabolism, using animal models, genetic studies, and human cohorts.
eLife · Feb 12, 2026Peer-reviewedGenetics