The paper develops MEIOSA to test biocompatibility of 3D-printed resins using oocytes and finds Parylene-C coating prevents toxicity in all tested resins.

bioRxiv · Jun 10, 2026 · PreprintBioengineering

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer

Khalil Almotah, Uyen Tran, Haylee Gilbert, Robert Allen Schweickart, Robert C. Fisher, Yaroslav Bisikalo, Manal Ali, Munir H. Buhaya, Mingyuan Cheng, Michael W. Cruise, Zhikai Chi, Samaneh Kamali Sarvestani, Emina H. Huang, Oliver Wessely

This study investigates how inflammatory fibroblasts in ulcerative colitis and colitis-associated cancer contribute to disease progression through senescence and epigenetic memory.

bioRxiv · May 20, 2026 · PreprintCancer Biology

A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses.

Jeffrey W. Pippin, Courtney R. Armour, D. Y. Eng, Uyen Tran, Robert Allen Schweickart, Natalya Kavarina, Kim Dill-McFarland, Oliver Wessely, Stuart J. Shankland

This study identifies regional transcriptomic differences in mouse podocytes during injury, revealing distinct gene expression patterns and potential therapeutic targets in focal segmental glomerulosclerosis.

bioRxiv · Mar 6, 2026 · PreprintBioinformatics

SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS

Christopher P. Chaney, Jeffrey W. Pippin, Uyen Tran, Diana G. Eng, Juliang Wang, Thomas J. Carroll, Stuart J. Shankland, Oliver Wessely

This study uses single-nucleus transcriptomics to analyze age-related changes in mouse kidney regions, revealing region-specific and cell-type-specific aging patterns in podocytes.

bioRxiv · Mar 2, 2026 · PreprintBioinformatics

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD

Uyen Tran, Andrew J. Streets, Devon Smith, Decker Eva, Annemarie Kirschfink, Lahoucine Izem, Jessie M Hassey, Briana Rutland, Manoj Kumar Valluru, Jan Hinrich Bräsen, Elisabeth B. Ott, Daniel Epting, Tobias Eisenberger, Albert C.M. Ong, Carsten Bergmann, Oliver Wessely

This study shows BICC1 interacts with PKD1 and PKD2, exacerbating ADPKD severity through RNA metabolism, using animal models, genetic studies, and human cohorts.

eLife · Feb 12, 2026Peer-reviewedGenetics

A poly(A) isoform-aware single-cell and spatial atlas defines fibroblast niches in the human bladder

Briana A. Santo, Emily E. Fink, P. Desprez, Yi‐Chia Lin, Mohamed M. Eltemamy, Alvin Wee, N.T. Le, Alexandra E Krylova, Uyen Tran, Veena Kochat, Kunal Rai, Douglas W. Strand, Oliver Wessely, Byron Lee, Angela H. Ting

The paper creates a poly(A) isoform-aware single-cell and spatial atlas of the human bladder, identifying fibroblast niches and their spatial relationships.

bioRxiv · Dec 18, 2025 · PreprintMolecular Biology

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

Mark A. Watson, Pooja Raj Devrukhkar, Natalia Murad, Fan Wu, Moo Joong Kim, Hannah Anvari, Uyen Tran, Nicholas G. Martin, Tommy Tran, Giuliana Zaza, Kevin Schneider, Bikem Soygur, Elisheva D. Shanes, Denis Wirtz, Mary Ellen Pavone, , Birgit Schilling

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

bioRxiv · Dec 8, 2025 · PreprintCell Biology

Ureter single-cell and spatial mapping reveal cell types, architecture, and signaling networks

Emily E. Fink, Surbhi Sona, Uyen Tran, P. Desprez, Matthew Bradley, Hong Qiu, Mohamed M. Eltemamy, Alvin Wee, Madison Wolkov, Marlo M. Nicolas, Booki Min, Georges‐Pascal Haber, Oliver Wessely, Byron Lee, Angela H. Ting

The paper maps cell types, architecture, and signaling networks in the human ureter using single-cell and spatial transcriptomics to inform tissue engineering strategies.

bioRxiv · Dec 22, 2021 · PreprintDevelopmental Biology