The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health
Nicki Dyson, Rayomand S. Khambata, Tipparat Parakaw, Gianmichele Massimo, Ngan HH. Khuat, Annika A. Noor, Lorna C. Gee, Ivy Lim, Umme Siddique, Andrew J. Sullivan, Jonathan W. Ho, Krishnaraj Sinhji Rathod, Michael R. Barnes, Claudia Cabrera, Amrita Ahluwalia
This study investigates the role of XOR-derived nitric oxide in cardiovascular health using Xdh-deleted mice, finding that reduced nitrite reductase activity leads to endothelial dysfunction and hypertension.
Redox Biology · Nov 8, 2025Peer-reviewedPharmacology & Toxicology